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Asprey, once a novelty in the biohacking and self-experimentation space, has managed to elevate his message to normies

[31] No allergic effects against OHCbl were seen in a study at dosages below 2.5 gm although higher dosages from 5 g to 7.5g showed effects in few volunteers ranging from itching, facial erythema, swelling, eye reddening, shivering, dyspnoea, facial oedema, and spontaneous exanthema

Mild redness or tenderness at the injection site is possible but temporary

If you find that post-injection insomnia is a problem, morning injection may be the better choice regardless of the sleep-through-symptoms advantage