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Moreover, CYP450s mediated metabolic activation are categorized into three categories, pyrrolizidine alkaloids, furan derivatives, epoxy diterpenoids, anthraquinones aristolochic acids, bisbenzylisoquinoline, alkenylbenzenes, based on the types of potentially toxic natural products

Four fatalities due to DILI occurred

In thisstudy, we obtained gmhA mutants carrying deletions of the cysB and cysE genes that regulate cysteine homeostasis, cysteine transport ( eamA ), and overexpress the cystine transport gene ( tcyP ), as well as deletions of gshA and gshB glutathione biosynthesis genes (Fig

Acid-triggered release of doxorubicin from a hydrazone-linked Gd 3+ -texaphyrin conjugate