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Pathogenesis of inflammation in skin disease: from molecular mechanisms to pathology

In our targeted single cell RNA-sequencing experiment, we observed that after 6 months of zinc supplementation, naive CD8+ T cells increased the expression of genes associated with maturation (PIK3IP, TRAC), differentiation and migration to the lymph nodes (CCR7) where they develop immune responses to novel viral or tumoral antigens

In cohort 1B, efficacy was greater according to PD-L1 expression: 63.2% (PD-L1 90% of cases) and other solid tumors, implicated in their pathogenesis and invasiveness [84-86]