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NIH Magnesium National Center for Complementary and Integrative Health

Research into metabolic decline often reveals a "NAD+ sink," where the body consumes more NAD+ than it can produce, leading to mitochondrial "misfiring" and cellular senescence

In murine models of cachexia, ketogenic feeding preserved lean mass and extended survival, an outcome attributed to reduced systemic IL-6 and TNF- as well as direct effects of ketone bodies (primarily -hydroxybutyrate) on muscle proteolysis 376,377,378