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For example, addition of exogenous complex I substrates, such as glutamate plus malate, or -KG, significantly augmented NADH levels and mitochondrial membrane potential, which stimulated H 2 O 2 production by 10-fold in isolated rat brain mitochondria (95)

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While this can provide short-term relief, prostaglandins play essential roles far beyond pain (27)

In addition, the NCF1 gene interacts with other NOX subunits with significant roles in innate immunity, produces ROS, reduces the gravity and duration of infections and autoimmune diseases, and is involved in T-cell activation