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doi: 10.1002/14651858.CD006316.pub3 53 SumitaniMTochinoYKamimoriTFujiwaraHFujikawaT

(2006) 136:1940S6S

The molecule is structurally modified with an N-terminal trans-3-hexenoyl group, which dramatically reduces its susceptibility to dipeptidyl peptidase IV (DPP-IV) degradation, the enzyme that breaks down natural GHRH