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Additionally, PARP inhibitors (PARPi) demonstrate significant clinical efficacy in BRCA-mutated patients (124), but emerging resistance limits their long-term effectiveness (125), Patients may develop resistance through multiple mechanisms, such as secondary BRCA gene mutations or restoration of DNA repair pathways (126)

Antimalarial drugs such as pamaquin are oxidizing compounds that deplete reduced glutathione

Survival assay Measurement of life span in wild type and park 13 flies was essentially performed as per established protocols 58

Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging