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Wu S-H, Mou C-Y, Lin H-P

Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, Carr SA, Thadhani R, Gerszten RE, Mootha VK (2008) Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

For virotherapy applications, incorporation of cancer-targeting peptides into the HI loop of the adenoviral fibre knob, the capsid protein that interacts with the native adenoviral receptor coxsackie adenovirus receptor (CAR) for cell entry, is an opportune targeting strategy for developing high-affinity, retargeted HAdV vectors [7]

Because Phase I leaves behind dangerous, reactive intermediates, Phase II must quickly neutralize them