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in vitro studies have provided useful insights into potential mechanisms of action and pre-clinical studies have indicated promising efficacy of IVC, however, clinical studies have so far been limited primarily to Phase I safety and pharmacokinetic trials (Parrow et al., 2013)

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Study Characteristics The 15 included trials were conducted across Italy (n=9), the United States (n=3), Russia (n=1), Iran (n=1), and India (n=1), and were published between 1983 and 2024