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Cobalamin Supplementation There are two primary routes: Parenteral (Injection) 2501,000 g subcutaneously once weekly for 46 weeks Followed by monthly maintenance if required Oral (Cyanocobalamin or Methylcobalamin) High-dose oral B12 (e.g., 250500 g/day) can be effective even in dogs with malabsorption due to passive diffusion Methylcobalamin may be more bioavailable, though veterinary research is still emerging 2

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Studies highlight its ability to expedite injury recovery, particularly in musculoskeletal soft tissues like the achilles tendon, by supporting tendon outgrowth and wound healing

Basic pharmacokinetic parameters including absorption, distribution, metabolism, and excretion characteristics in human subjects would inform rational dosing strategies and identify potential sources of pharmacokinetic variability affecting individual response