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The importance of polyfilament proteins to epidermal barrier homeostasis has been shown in mouse models and human diseases, where this protein is aberrantly expressed in patients with common ichthyosis and atopic dermatitis [65,68,69]

Activation of PARP-1 by parthanatos induces the release of immunogenic alarmins, primarily of HMGB1

These microenvironmental constraints can limit iron availability, activating adaptive pathways such as HIF-1, which promotes metabolic adaptation and tumor invasiveness ( Due to their rapid growth and proliferation, tumor cells have an increased demand for iron, disrupting iron metabolism