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These mutations showed similar affinity enhancement for CTR ECD alone with pK I 6.74 to 7.06 (K I 86 nM to 183 nM) (Figure 8E, 8F and Table 2)

The phase 3 SURMOUNT programme assessed the safety and efficacy of tirzepatide as obesity treatment and the medication has now been approved (November 2023) for chronic weight management by the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) [46, 47]