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Statistical analysis Statistical analysis was performed by parametric one-way ANOVA with post hoc Newman-Keuls test and non-parametric Kruskal-Wallis and subsequent Mann-Whitney U -test to compare groups

IDD has a complex etiology that is usually linked to genetic and environmental variables (Vo et al., 2016), smoking (Nasto et al., 2014), infection (Stirling et al., 2001), mechanical overload (Vadala et al., 2015), trauma (Russo et al., 2017), and diabetes (Russo et al., 2019)