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Guidance for industry: Bioavailability and bioequivalence studies for orally administered drug products General considerations

Common research-planning ranges (subcutaneous) Planning band Low Per-dose range ~250 mcg Frequency Once daily Typical context Maintenance / general research planning Planning band Standard Per-dose range ~250 mcg Frequency Twice daily Typical context Most published preclinical protocols and community references Planning band High Per-dose range ~500 mcg Frequency Twice daily Typical context Short-term acute-injury research planning These ranges reflect community-derived research planning