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Supporters describe it as working beyond the gut

The same body weight, dose-response relationship cannot be assumed to hold true for older adults, and the risk of sarcopenia and reduced bone density with significant weight loss needs to be considered

The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

It is classified as an unapproved drug and is on the U.S