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Furthermore, Tfam -specific knockout in mouse T cells disrupted mitochondrial genome integrity and induced an aberrant Th1-type pro-inflammatory response, characterized by enhanced expression of T-bet, IFN- and TNF-, resulting in increased senescence, neuromuscular and vascular dysfunction, and reinforced molecular features that recapitulate premature ageing
Begin once daily, increase based on skin comfort
TABLE 1 Molecular and biological effects of endogenous estrogen and estrogen-like molecules in NSPCs