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Key Principles Moving Forward As this field evolves, several principles should guide research and clinical application: Evidence-based approaches Rely on clinical trial data rather than speculation Safety prioritization Careful monitoring and gradual titration to minimize risks Individualization Recognize that response varies significantly between individuals Comprehensive support Combine peptide therapy with lifestyle optimization Professional collaboration Maintain communication between researchers, clinicians, and support professionals Actionable Next Steps For health professionals, researchers, and wellness practitioners: 1

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Due to disassembly of the complex upon dilution to nanomolar concentrations required for mass photometry, we stabilised it by limited crosslinking using glutaraldehyde prior to dilution to assess potential TRF1 dissociation (Supplementary Fig

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