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These results describe a system of aminoglycoside-induced cell death that both shares molecular targets but also has unique features depending on aminoglycoside and exposure time

Demonstrating our idea from the reverse aspect, the Chinese herb Sedum sarmentosum extract (SSB) reduced the activity of the NF-B signaling pathway when exerting renoprotective effects ( in vivo , including the imbalance of extracellular matrix (ECM) accumulation and matrix metalloproteinase (MMP) activation involving NF-B (Tsai et al., 2014)

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This is the highest local concentration possible and produces the strongest local regenerative signal