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Negative emotions such as anxiety and depression reduce vagal tone, weaken parasympathetic pro-motility effects on the gut, and reduce intestinal motility, while abdominal discomfort and psychological distress caused by constipation activate the sympathetic nervous system, further inhibiting intestinal motility and forming a vicious cycle

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5-Amino-1MQ has not been approved by the FDA or any regulatory body for human therapeutic use.

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