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The pre-treatment of IWP2, an inhibitor preventing secretion of Wnt ligands, abrogated Wnt/-catenin activation

MAM is a consultant for Boehringer-Ingelheim, SoseiHeptares, and Neurocrine and sits on the advisory board for Quolet

Antioxidant Support : Glutathione is known as a master antioxidant that can protect the skin from free radicals and reduce oxidative stress

* Require JNK activation for cytotoxicity The link between GSTs and the MAP kinase pathway provides a rationale as to why many of the selecting drugs are neither subject to conjugation with GSH, nor substrates for GSTs (Tew, 1994)