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This typically becomes noticeable 2 to 3 weeks after the final dose, when circulating retatrutide levels have dropped below the therapeutic threshold

However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months