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SNAC functions through a multifaceted mechanism: it buffers the local gastric pH, thereby protecting semaglutide from acidic degradation and proteolytic enzymes, and enhances drug solubility and monomerization

2.5 Model Predictions Because of substantial log-normal within-individual variability, standard computation of reference subject simulations, as well as population predictions and weighted residuals reported by the nonlinear mixed-effects modelling software (NONMEM) are poor measures to reflect data

Laboratory Investigation, 96 (4), 378390

[DOI] [PubMed] [Google Scholar] 7.Veber DF, Johnson SR, Cheng HY, Smith BR, Ward KW, Kopple KD