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Funding This work was supported and funded by the Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU) (grant number IMSIU-DDRSP2601)

This concept, however, also implies that the uncoupling of eNOS is mediated by ONOO and would invariably require a primary superoxide anion source such as the Nox, xanthine oxidase or mitochondria

25 The 1970s saw significant progress in identifying mitochondrial metabolism defects through histochemical assays, including deficiencies in pyruvate dehydrogenase, carnitine, cytochrome c oxidase, and carnitine palmitoyltransferase