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Most of these estimations do not use factual data (other than PM2.5 levels) from the studied location with no attempt to modulate the impact of air pollution on mortality (ex: data is often calibrated in cities where industrial, traffic and urban pollution is potentially considerably more toxic than biomass burning or desert dust)

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Although often perceived as safer than combustible cigarettes, mounting evidence confirms neurotoxic effects of nicotine in e-cig aerosols, and indicates that components other than nicotine can be detrimental to the developing brain

Each stage brings its own challenges and timelines: 1