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In HCC, ERS is implicated in tumor cell proliferation, migration, invasion, angiogenesis, and resistance to chemotherapy

389,390,391 Environmental toxins and neurodegenerative disorders Exposure to various types of environmental toxins including trace metals as just discussed, but also pesticides such as organophosphates, substances of abuse such as methamphetamine, organic solvents, air pollutants, and others are increasingly recognised as risk factors in neurodegenerative disorders such as PD and others