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2014) reported that resveratrol derivatives possessed multitarget neuroprotective activities, including potent inhibition of AChE and BuChE (IC 50 as low as 0.32 M), suppression of A 142 aggregation, and monoamine oxidase inhibition (IC 50 down to 1.75 M), significantly outperforming native resveratrol and suggesting enhanced efficacy against Alzheimer's pathology

Supplemental studies have shed light on the upstream mechanism of this signaling pathway, demonstrating that sUA provokes IR in HUA by stimulating the Nuclear factor erythroid 2-related factor 2 (Nrf2)/Heme Oxygenase 1(HO-1) signaling pathway and upregulating the regulatory thioredoxin interacting protein (TXNIP), thereby inhibiting the IRS2/PI3K/AKT signaling pathway in macrophages (57)

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