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ADA 2025: CagriSema Demonstrates Significant Weight Loss in REDEFINE Clinical Trials Kennedy Ferruggia, Associate Editor Luke Halpern, Associate Editor Key Takeaways CagriSema demonstrated significant weight loss and metabolic improvements in individuals with obesity, outperforming semaglutide, cagrilintide, and placebo

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Many GLP-1 patients benefit from the energy support, but we review labs and caloric intake to make sure the combination is appropriate

In contrast, genes related to gram-positive competence were elevated in the control group, along with putrescine utilization and carotenoid pathways