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Specifically, in addition to anti-thyroid stimulating hormone receptor (TSH-R), Abs have also been found to target insulin-like growth factor 1 receptor on orbital fibroblasts [155], which results in the synthesis of hyaluronan and secretion of interleukin (IL)-1 to IL-16, effectively recruiting autoreactive T cells [156]

It is unfortunate that these promising observation have been never published and therefore the precise parameters remain unknown