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NNMT is an enzyme that transfers a methyl group from S-adenosyl-L-methionine to nicotinamide, producing 1-methylnicotinamide and S-adenosyl-L-homocysteine

Functional Always active

The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism

Furthermore, this vitamin plays a significant role in regulating the nervous system, which may help reduce symptoms of depression and stress, as well as mitigate the risk of brain atrophy