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In addition, the oxidants may also originate from cytosolic enzyme systems, e.g., NADPH oxidases, and from exogenous triggers such as ionizing radiation and chemotherapeutics

Langman CB, Greenbaum LA, Grimm P, Sarwal M, Niaudet P, Deschenes G, Cornelissen EA, Morin D, Cochat P, Elenberg E, Hanna C, Gaillard S, Bagger MJ, Rioux P (2014) Quality of life is improved and kidney function preserved in patients with nephropathic cystinosis treated for 2 years with delayed-release cysteamine bitartrate

In cases where the possibility of developing CVD is significant, it may be imperative to implement pharmacological measures to modify risk factors

For the competitive experiment, HCT116 cells were incubated with 5-fold RNK06138 (5 M) mixed with RNK06389 (1 M) for 12 h, the cellular fluorescence was significantly reduced in the presence of RNK06138 (Fig