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By inhibiting NNMT, 5-Amino-1MQ increases intracellular nicotinamide availability for NAD+ biosynthesis via the salvage pathway, thereby modulating cellular NAD+ levels and NAD+-dependent signaling processes

However, in patients treated with diclofenac and glucocorticoids, the risk of peptic ulcer and gastrointestinal bleeding may increase, so special attention should be given in case of prolonged treatment, even in the absence of serious gastrointestinal symptoms

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