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Oxidative stress as a mechanism of diabetes in diabetic BB prone rats: effect of secoisolariciresinol diglucoside (SDG)

It is also worth noting that animal model studies have illustrated a mechanistic contribution of microbial TMA and TMAO generation to enhanced development of atherosclerosis, platelet reactivity and thrombosis, and both impairment in renal function and fibrosis, as well as adverse ventricular remodeling and heart failure (refs