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In the same mouse model, a decreased glycolytic capacity was demonstrated in the optic nerve ( Metabolomics analyses of whole glaucomatous retina in animal models have identified potential changes to several metabolic pathways including alanine, aspartate and glutamate metabolism, D-glutamine and D-glutamate metabolism, and arginine biosynthesis ( Supporting the widespread dysregulation of multiple metabolic pathways, human genetic analysis has also identified the potential for changes to mitochondrial lipid metabolism in both POAG and NTG

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