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Shalev et al., 2000

Consistently, in HepG2 hepatocytes, capsaicin activates AMPK, increases PGC-1 abundance, improves mitochondrial function, and suppresses lipogenesis, linking mitochondrial biogenesis to coordinated control of lipid metabolism (10)

a few studies demonstrate distinct changes to cortisol and the Cortisol Awakening Response (CAR), which may suggest that insomnia disorder is characterised by elevated HPA axis activity