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doi: 10.1016/0090-6980(81)90123-4

How does the mechanism of sodium channel blockade by Lidocaine and Mexiletine contribute to their differential effectiveness in treating ventricular arrhythmias

MAPK pathway suppression: KPV also dampens MAP kinase signaling, limiting further downstream cytokine cascades beyond NFB

This includes bradyarrhythmias, in which the heart rate is slower than 60 beats per minute (bpm), and tachyarrhythmias, in which the heart rate exceeds 100 bpm