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These receptors are distributed throughout various tissues and cell types, mediating a wide range of physiological responses, including inflammation, vascular tone regulation, and nociception (see Table 2)

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HFD impairs liver glutathione biosynthesis, vitamin D metabolism genes and genes associated with non-alcoholic fatty liver disease (NAFLD) Genes involved in the GSH biosynthesis pathway were significantly downregulated in the livers of mice fed an HFD compared to those of mice fed a healthy diet (controls) (Fig