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Polymeric NPs can either breach the BBB via surface functionalization, for instance using Abs directed against endothelial cell surface receptors leveraging the RMT route, or negatively charged on their surface, for intravenous applications, as described above in sections Different mechanisms of transport across the blood-brain barrier and Effect of nanoparticles surface charge and also reviewed in Saraiva et al

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These data confirmed the involvement of Src kinase, PKC, and MEK in the enhancement of daidzein-mediated neurite outgrowth [74]