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Because NNMT is involved in methylation and metabolic control, 5-Amino-1MQ is of interest in: Characterizing NNMT as a potential biomarker of tumor metabolism Studying how NNMT modulation may influence cancer cell proliferation, redox balance, and methyl-donor utilization Evaluating NNMT as a possible experimental target in oncology research At present, these efforts are confined to laboratory research

NADPH plays an important role in maintaining a favorable cellular redox environment, producing reactive oxygen species (ROS) via NADPH-dependent enzymes but also in preventing cellular oxidative stress (TeSlaa et al., 2023)

Disclosures: Harsh Tevethia: Nothing to Disclose, Akhil Deshmukh: Nothing to Disclose, Ankur Jindal: Nothing to Disclose, Guresh Kumar: Nothing to Disclose, Shiv Kumar Sarin: Nothing to Disclose 2264 PATIENTS WITH CIRRHOSIS AND A HISTORY OF OVERT HEPATIC ENCEPHALOPATHY EXPERIENCED LOWER 6-MONTH ALL-CAUSE MORTALITY RATES WITH RIFAXIMIN MONOTHERAPY VERSUS LACTULOSE MONOTHERAPY Jasmohan Bajaj 1 Robert Rahimi 2 Christopher Allen 3 Zeev Heimanson 3 Robert Israel 3 Kris Kowdley 4 , 1 Virginia Commonwealth University and Central Virginia Veterans Healthcare System, 2 Baylor University Medical Center, 3 Salix Pharmaceuticals, 4 Liver Institute Northwest and Elson Floyd College of Medicine Background: Hepatic encephalopathy (HE) is associated with a poor prognosis, and data suggest that rifaximin use may improve survival

3,8 Additional effects of GLP-1 include slowing gastric emptying, reducing appetite, and aiding in weight loss