glutathione genes Synthase - an overview Glutathione in Brain Disorders and

IRON DEPOSITION MODULATES THE PROTEIN TURNOVER OF -SYN Although iron directly influences -syn aggregation through structural interactions, iron deposition can also indirectly modulate both -syn protein levels and fibrillization through three key mechanisms: (1) altering Iron deposition promotes -syn synthesis Iron homeostasis in humans is regulated by the interaction between iron-regulatory proteins (IRPs) and iron-responsive elements (IREs) [19]

Mearin F, Lacy BE, Chang L, Chey WD, Lembo AJ, Simren M, et al

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145 Ractigen Therapeutics has submitted an Investigational New Drug application for RAG-01, and it is expected to become the second saRNA drug to enter clinical trials internationally