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Activated CD8+ T cells treated ex vivo with simultaneous inhibition of A2AR and lipid peroxidation acquire a superior capacity to proliferate and persist in vivo, demonstrating a translatable means to prevent ferroptosis in adoptive cell therapy

Indeed, upon genetic ablation of the copper uptake transporter CTR1, a maneuver that lowers intracellular copper, autophagy is decreased in a mouse model of KRAS-driven lung cancer, paralleled by a sizeable reduction of tumorigenesis