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Instead, we observed a slight reduction in H3K4me3 and H3K9me3 following 11 days of treatment, indicating that despite ABHD11 inhibition leading to decreased OGDHc activity, there was no evidence that 2-OGDDs were inhibited

A subset of the genes related to gene transcription ( CDK6 , EGR2 , MYC and ZNF493 ), cell adhesion ( AFAP1 , CRMP1 , PSD2 and THBS2 ) and stress responses ( AOX1 , GPX2 , HSPB7 and SIRT6 ) was significantly related to the OS of BC patients from the TCGA datasets, and the altered expression of these biomarkers was dependent on tumor grade or pT category (Fig