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No large-scale, randomized placebo-controlled trials have established efficacy or formal indications for BPC-157

doi: 10.1177/1098612X18774709

However, ADH is considerably more sensitive to small changes in osmolality than changes in blood volume: a 1% decrease of plasma osmolality stimulates ADH secretion, whereas a 10% decrease in blood volume is necessary to clearly increase ADH levels ( Guyton and Hall 2006 )