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Additionally, the upregulation of AE2 on biliary epithelial cells further supports bicarbonate secretion, contributing to UDCAs beneficial effects on bile composition ( Furthermore, UDCA has been shown to reduce the hepatocellular and biliary expression of major histocompatibility complex (MHC) class I and II proteins, which are involved in immune-mediated liver damage, suggesting that UDCA may mitigate T-cell-mediated hepatocellular injury in PBC ( In addition to its effects on bile secretion and immune modulation, UDCA provides direct cytoprotection to hepatocytes and biliary epithelial cells through several mechanisms

While L-LTP is unaffected in the hippocampus of Fmr1 /y mice (Paradee et al., 1999

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Archived from the original on 2008-06-11