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11 Interestingly, all of these haplotypes were associated with a significant decrease in the serum SN-38G/SN-38 concentration ratio, which provides evidence that multiple combinations of polymorphisms in the UGT1A1 gene are associated with decreased capacity to inactivate SN-38 by glucuronidation

Similarly, other studies suggest that inhibition of mitochondrial complex I activity and facilitation of -synuclein aggregation may be closely associated with rotenones selective dopaminergic toxicity in neurons [14,65]