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6.2 Thioredoxin Structure The TRX active site contains a conserved sequence (CysGlyProCys) and belongs to a TRX superfamily, in which all members share similar active site sequences CysXYCys)

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7 A number of NMDA antagonists have been reported to rapidly reversewithin a few hourssevere and chronic depression when administered intravenously (ketamine, rapastinel, scopolamine), intranasally (S-ketamine), or via inhalation (nitrous oxide)