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Enhanced Redox Homeostasis via Upregulation of the Pentose Phosphate Pathway Our study reveals a rearrangement of the PPP, increased levels of oxPPP enzymes, and higher production of glutathione from glucose-derived metabolites during early neuronal differentiation, suggesting an adaptive response to a potential increase in oxidative stress

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Elevated Toll-like receptor 4 (TLR4) expression in PAECs, PASMCs, and immune cells, along with the activation of the TLR4-NF-B signaling pathway, is a widespread pathological feature of PH

Am J Pathol 1976;85:20928