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499 Sareptas SRP-5051, an ASO conjugated with a targeting peptide, has shown higher levels of dystrophin expression and exon skipping rates than eteplirsen

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There is also a basic characterization step that would help before any of that: independent analytical confirmation of what is actually in research vials peptide purity, the true copper-to-peptide ratio, and the absence of endotoxin and contaminants so that findings can be tied to a defined substance rather than to material of unknown composition

d , Quantification of MitoSOX red fluorescence in animals as depicted in ( c )