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Scientific Reports 8:3660

Lack of vitamin B12, homocysteine and inflammation Finally, most studies agree there is a direct correlation between joint pain, especially that caused by rheumatoid arthritis, and elevated homocysteine, a pro-inflammatory amino acid (7)

Originally developed to study metabolic disorders and insulin resistance , 5-Amino-1MQ has now gained attention in fitness and longevity circles for its ability to: Reduce fat cell size Increase NAD levels (critical for energy and mitochondrial function) Enhance insulin sensitivity and metabolic efficiency When NNMT is overactive as is often the case with obesity, aging, and chronic disease it limits the availability of nicotinamide and reduces NAD production