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However, in glutathione synthetase deficiency, because the activity of gamma-glutamyl-cysteine synthetase is regulated via feedback inhibition by glutathione, gamma-glutamyl-cysteine and then L-5-oxoproline are overproduced, resulting in the metabolic acidosis and urinary excretion of this compound at levels several hundred-fold above normal (71

6.1.2 Gut-derived factors Intestinal I/R injury leads to the leakage of gut-derived factors such as bacterial endotoxins (lipopolysaccharide, LPS), metabolites, and cytokines into the bloodstream (Nie et al., 2024)

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European Journal of Pharmacology 794: 173-183.Google Scholar LU, Y., ZHANG, C., BUCHELI, P