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The comparison that needs to be made is effectiveness vs side effects

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These patients have a predominance of visceral obesity or lipodystrophy, and the body mass index (BMI) may not be sufficiently to define LEAN-P with NAFLD

for instance, glycine and serine are glutamine-derived and are important suppliers of the folate cycle from one-carbon metabolism (as reviewed by The enzymes involved in both cysteine catabolism and anabolism, CBS and CSE, are frequently associated with malignancy and more aggressive cancer phenotypes (124, 127, 142147), suggesting that at least one of the two pathways are relevant in cancer, and they might be working simultaneously as a way to keep on moving the metabolic cellular network